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雷帕霉素

分析標(biāo)準(zhǔn)品,HPLC≥99%

Sirolimus

CAS號：53123-88-9

分子式：C51H79NO13

分子量：914.18

MDL：MFCD00867594

別名：西羅莫司;瑞帕霉素

產(chǎn)品介紹

 Rapamycin (Sirolimus) (GMP) 是 GMP 級別的Rapamycin (HY-10219)。GMP 級別的小分子可用做細(xì)胞療法中的輔助試劑。Rapamycin 是一種有效且特異性的 mTOR 抑制劑。 

熔點：183-185℃

沸點：973.017 ℃ at 760 mmHg

比旋光度：D25 -58.2° (methanol)

外觀：黃色固體（類白色固體）

溶解性：DMSO：100mg/ml（需超聲）

敏感性：對熱敏感

儲存條件：-20℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(45篇)

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12.  Li, Cuijie, et al. "Epidermal growth factor regulation by autophagy‐mediated lncRNA H19 in murine intestinal tract after severe burn." Journal of cellular and molecular medicine 24.10 (2020): 5878-5887.https:##doi.org/10.1111/jcmm.15262

11.  Li, Cuijie, et al. "Long noncoding RNA H19 act as a competing endogenous RNA of Let‐7g to facilitate IEC‐6 cell migration and proliferation via regulating EGF." Journal of cellular physiology 236.4 (2021): 2881-2892.https:##doi.org/10.1002/jcp.30061

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9.  蔣鵬娜,王麗潔,李星,李竹英.平喘顆粒對氣道上皮細(xì)胞自噬及凋亡的抑制作用探討[J].中國中醫(yī)急癥,2020,29(11):1902-1905.

8.  饒春梅 成細(xì)華 任婷 孫彥波 彭霞 黃政德.加味丹參飲含藥血清預(yù)處理對缺氧/復(fù)氧H9C2心肌細(xì)胞自噬相關(guān)基因Atg5和Beclin1 mRNA表達(dá)的影響[J].中國老年學(xué)雜志 2017 37(08):1821-1824.

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6.  劉波, 陳澍, 杜心靈,等. 雷帕霉素降低炎癥因子表達(dá)水平對小鼠心肌梗死的影響[J]. 華中科技大學(xué)學(xué)報:醫(yī)學(xué)版, 2013, 42(4):391-391.

5.  單冬煒,經(jīng)濤,沈建華,丁冬官,祝兵,謝平,于惠敏.雷帕霉素在視網(wǎng)膜母細(xì)胞瘤嬰幼兒患者中的應(yīng)用及對預(yù)后的影響[J].腫瘤藥學(xué),2017,7(05):605-609.

4.  蔡旭華,朱偉華,李偉平.西羅莫司對非酒精性脂肪肝大鼠調(diào)節(jié)性T細(xì)胞/輔助性T細(xì)胞17平衡的影響[J].中國臨床藥理學(xué)雜志,2017,33(01):36-39.

3.  郭娟, 張迪, 李龍,等. 細(xì)胞自噬對犬骨髓間充質(zhì)干細(xì)胞干性的影響[J]. 畜牧獸醫(yī)學(xué)報, 2020, v.51(02):166-174.

2.  陸樹萍, 丁紅生. 紅景天苷經(jīng)自噬途徑減少腦出血后繼發(fā)神經(jīng)損傷的的機(jī)制探討[J]. 中華中醫(yī)藥學(xué)刊, 2019(4).

1.  李竹英,田春燕,蔣鵬娜,馬建.基于PI3K/Akt/mTOR信號通路探討平喘顆粒對氣道上皮細(xì)胞自噬的作用機(jī)制[J].中華中醫(yī)藥雜志,2019,34(11):5094-5098.

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